解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Studies have demonstrated considerable variability in systemic lupus erythematosus (SLE) incidence and prevalence estimates. Lack of reliable epidemiological data may hinder evidence-based health care planning. The aim of the present study was to estimate the prevalence and incidence of SLE in the Estonian adult popul...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316686705
更新日期:2017-09-01 00:00:00
abstract::Objectives The carotid intima-media thickness (CIMT) and carotid arterial stiffness index (CASI) act as the surrogate markers of atherosclerosis. We aim to assess CIMT and CASI in pediatric systemic lupus erythematosus (SLE). Methods Patients ≤ 20 years old fulfilling diagnostic criteria for SLE were enrolled. Patient...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203317692434
更新日期:2017-08-01 00:00:00
abstract::Objective People affected by chronic rheumatic conditions, such as systemic lupus erythematosus (SLE), frequently rely on the Internet and search engines to look for terms related to their disease and its possible causes, symptoms and treatments. 'Infodemiology' and 'infoveillance' are two recent terms created to desc...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203317691372
更新日期:2017-07-01 00:00:00
abstract::Introduction Osteoprotegerin (OPG) is a member of the tumor necrosis factor (TNF) receptor family. It has recently been demonstrated that OPG is produced by a variety of tissues, including the cardiovascular system (heart, arteries, veins), lung, kidney, immune tissues, and bone. The OPG-RANKL signaling pathway is str...
journal_title:Lupus
pub_type: 杂志文章,随机对照试验
doi:10.1177/0961203316682101
更新日期:2017-07-01 00:00:00
abstract::Immune-mediated sensorineural hearing loss may complicate systemic autoimmune diseases. We have previously reported the presence of antibodies directed against inner ear antigens in patients with Cogan syndrome, a disease characterized by sudden hearing loss and interstitial keratitis. Such autoantibodies cross-react ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316682099
更新日期:2017-07-01 00:00:00
abstract::Objectives The objective of this paper is to study the time trend and risk factors of avascular bone necrosis (AVN) in patients with systemic lupus erythematosus (SLE). Methods Between 1999 and 2014, patients who fulfilled the ACR criteria for SLE and developed symptomatic AVN were identified from our cohort database ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316676384
更新日期:2017-06-01 00:00:00
abstract::Background Systemic lupus erythematosus (SLE) is an autoimmune disease marked by the disruption of the immune homeostasis. Patients exhibit a wide range of clinical manifestations, and environmental and genetic factors are involved in SLE pathogenesis. Evidence suggests that abnormalities in the cellular and molecular...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316678671
更新日期:2017-06-01 00:00:00
abstract::Systemic lupus erythematosus (SLE), a disorder of the immune system, is potentially curable by allogeneic bone marrow transplantation (alloBMT). Until recently, alloBMT was limited by donor availability and toxicity. Reduced intensity conditioning (RIC) combined with post-transplantation cyclophosphamide (PTCy) has im...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316669242
更新日期:2017-06-01 00:00:00
abstract::Objective The objectives of this paper are to objectively measure habitual physical activity levels in patients with primary Sjögren's syndrome (pSS) with mild disease activity and to determine to which extent it may be associated with physical capacity and function and clinical features. Methods In this cross-section...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316674819
更新日期:2017-06-01 00:00:00
abstract::Objective The lupus impact tracker (LIT) is a 10-item patient reported outcome tool to measure the impact of systemic lupus erythematosus or its treatment on patients' daily lives. Herein, we describe the responsiveness of the LIT and LupusQoL to changes in disease activity, using the systemic lupus erythematosus resp...
journal_title:Lupus
pub_type: 杂志文章,多中心研究
doi:10.1177/0961203316667494
更新日期:2017-04-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a severe chronic inflammatory autoimmune connective tissue disease. Despite major efforts, SLE remains a poorly understood disease with unpredictable course, unknown etiology and complex pathogenesis. Apoptosis combined with deficiency in clearing apoptotic cells is an important e...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316669240
更新日期:2017-04-01 00:00:00
abstract::Objectives The objective of this study was to determine whether advanced MRI could provide biomarkers for diagnosis and prognosis in neuropsychiatric systemic lupus erythematosus (NPSLE). Methods Our prospective study included 28 systemic lupus erythematosus (SLE) patients with primary central NPSLE, 22 patients witho...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316674820
更新日期:2017-04-01 00:00:00
abstract::In 2012, the Systemic Lupus International Collaborating Clinics (SLICC) group published a new set of classification criteria for systemic lupus erythematosus (SLE). Studies applying these criteria to real-life scenarios have found either equal or greater sensitivity and equal or lower specificity to the 1997 ACR class...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316657434
更新日期:2017-03-01 00:00:00
abstract::Objective We aimed to evaluate the relationship between telomere length and systemic lupus erythematosus (SLE). Methods PUBMED and EMBASE databases were searched; meta-analyses were performed comparing telomere length in SLE patients and healthy controls, and on SLE patients in subgroups based on ethnicity, sample typ...
journal_title:Lupus
pub_type: 杂志文章,meta分析
doi:10.1177/0961203316662721
更新日期:2017-03-01 00:00:00
abstract::Objectives Lupus is a classical systemic autoimmune disease with genetics as one of the well known causative factors for the disease pathogenesis. Toll-like receptors are the major pattern recognition receptors associated with innate immunity and also act as an interface with the adaptive immunity. Genetic polymorphis...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316659151
更新日期:2017-03-01 00:00:00
abstract::We report a case of drug-induced lupus erythematosus (DILE) secondary to trimethoprim/sulfamethoxazole (TMP/SMX) in a patient with underlying inflammatory bowel disease (IBD). The initial presentation was with febrile pleural and pericardial effusions followed by cardiac tamponade. The patient was treated with a short...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316657435
更新日期:2017-03-01 00:00:00
abstract::Background Musculoskeletal involvement is extremely common in patients with systemic lupus erythematosus (SLE). Continuing the research initiated in patients with inflammatory arthritis, recent studies have shown the potential role of musculoskeletal ultrasound (MSUS) in the evaluation of clinical and subclinical lupu...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316662723
更新日期:2017-03-01 00:00:00
abstract::Q fever has extremely polymorphic features, and has been reported to be associated with positivity of several autoimmune antibodies. We report two cases of atypical Q fever with a clinical presentation highly suggestive of an inflammatory systemic disease with positivity of autoimmune antibodies, mimicking systemic lu...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203317747721
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:High-mobility group box 1 protein (HMGB-1) has been implicated in the pathogenesis of lupus nephritis (LN). There is increased HMGB-1 expression in the kidneys and increased levels are observed in serum and urine of patients with LN. This study was performed to determine whether the increased urinary HMGB-...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316644331
更新日期:2016-12-01 00:00:00
abstract::Proteinuria is the hallmark of clinical manifestation of disease activity in lupus nephritis (LN) patients, which arises from direct or indirect podocyte injury. This study is to explore the relationship between intrarenal T cell infiltration and podocyte injury in lupus nephritis (LN), and to understand the potential...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316646861
更新日期:2016-12-01 00:00:00
abstract::Background The prevalence and variation by ethnicity of cutaneous lupus in New Zealand is not known. Therefore, a cross-sectional study to determine the prevalence and variation by ethnicity of cutaneous lupus in the ethnically diverse community of South Auckland, New Zealand, was undertaken. Methods Multiple sources ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316651745
更新日期:2016-11-01 00:00:00
abstract::Analyses of the medical and economic burden of chronic disorders such as systemic lupus erythematosus (SLE) are valuable for clinical and health policy decisions. We performed a chart-based review of 215 adult SLE patients with active autoantibody-positive disease at the predefined ratio of 30% severe (involvement of ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316642310
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:This study aimed to explore whether TYK2 polymorphisms are associated with susceptibility to autoimmune rheumatic diseases. METHODS:We conducted a meta-analysis on the association between TYK2 polymorphisms and autoimmune rheumatic diseases. RESULTS:Twelve studies with a total of 16,335 patients and 30,065 ...
journal_title:Lupus
pub_type: 杂志文章,meta分析
doi:10.1177/0961203316638933
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:We aimed to develop a model of the illness experience for youth with systemic lupus erythematosus (SLE)/mixed connective tissue disease (MCTD). METHODS:We conducted 32 semi-structured interviews with 16 outpatient youth with SLE/MCTD, age 11 to 22 years, and their parents. We qualitatively defined key featur...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316646460
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:To determine whether the intrathecal concentrations of cytokines/chemokines are associated with, or influenced by, serum concentrations in patients with central neuropsychiatric systemic lupus erythematosus (NPSLE), and to ascertain whether the increased production of cytokines/chemokines intrathecally relati...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316629556
更新日期:2016-08-01 00:00:00
abstract::Although challenging, developing evidence-based approaches to an early and accurate diagnosis of systemic lupus erythematosus is a key approach to preventing disease and lupus-associated morbidity and mortality. Advances in our understanding of preclinical and incomplete lupus erythematosus have enabled the identifica...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203316640367
更新日期:2016-07-01 00:00:00
abstract::Detection of antineutrophil cytoplasmic antibodies (ANCA) for ANCA-associated vasculitides (AAV) is based on indirect immunofluorescence (IIF) on ethanol-fixed neutrophils and reactivity toward myeloperoxidase (MPO) and proteinase 3 (PR3). According to the international consensus for ANCA testing, presence of ANCA sho...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316640921
更新日期:2016-07-01 00:00:00
abstract::The undigested remnants of apoptosis are believed to stimulate the generation of autoantibodies in lupus. The biological properties of initiator, disease-specific IgM antibodies that specifically recognize apoptotic cells, readily detected in the sera of lupus patients, remain unclear. Apoptotic cell-reactive IgM mono...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315624023
更新日期:2016-06-01 00:00:00
abstract::Spondyloenchondrodysplasia (SPENCD) is a rare autosomal recessive skeletal dysplasia caused by recessive mutations in the ACP5 gene, and it is characterized by the persistence of chondroid tissue islands within the bone. The clinical spectrum of SPENCD includes neurological involvement and immune dysfunction, such as ...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203316629000
更新日期:2016-06-01 00:00:00
abstract::Cyclophosphamide (CYC) is used in severe neuropsychiatric systemic lupus erythematosus (NPSLE), but long-term data regarding its efficacy and safety are lacking. We identified NPSLE cases who received CYC from two centres during the period 1999-2013 and had regular follow-up. General and neuropsychiatric outcome at la...
journal_title:Lupus
pub_type: 杂志文章,多中心研究
doi:10.1177/0961203315622821
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship between antimalarials (AM) and elevated muscle enzymes in systemic lupus erythematosus (SLE). PATIENTSMETHODS:325 lupus patients with abnormal creatine phosphokinase (CPK) for at least two consecutive clinic visits were enrolled; 54 patients on statins/fibrates (n = 43) and/or...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315617845
更新日期:2016-04-01 00:00:00
abstract:INTRODUCTION:Patients with systemic lupus erythematosus (SLE) with B-lymphocyte stimulator (BLyS) levels ≥ 2 ng/mL are at increased risk of flare. A regression analysis was undertaken to identify routine clinical measures that correlate with BLyS ≥ 2 ng/mL. Efficacy and safety of belimumab 10 mg/kg were examined in pat...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315604909
更新日期:2016-04-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) has preponderance in women in their childbearing years; consequently pregnancy has always been an important issue of concern for the patient and the treating physician. Based upon numerous reports on successful pregnancy outcomes in the past decades, the initial advice against pregna...
journal_title:Lupus
pub_type: 评论,杂志文章
doi:10.1177/0961203315627201
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:The prevalence and severity of systemic lupus erythematosus (SLE) differs between ethnic groups and geographical regions. Although initially reported as rare, there is growing evidence that SLE is prevalent and runs a severe course in Africa. There is a paucity of prospective studies on African SLE patients....
journal_title:Lupus
pub_type: 杂志文章,多中心研究
doi:10.1177/0961203315606984
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:GlycA is a novel marker of systemic inflammation detected by nuclear magnetic resonance (NMR) spectroscopy. In the general population, GlycA is correlated with inflammatory markers such as C-reactive protein (CRP) and associated with coronary heart disease and diabetes. The utility of GlycA in patients with ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315617842
更新日期:2016-03-01 00:00:00
abstract:INTRODUCTION:Several studies have shown that Hispanic patients generally experience a worse renal prognosis than non-Hispanic white patients with lupus. To date, there is no report on American College of Rheumatology (ACR) renal response criteria (ACR-RRC) in patients from Latin America. OBJECTIVE:To evaluate treatmen...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315600537
更新日期:2016-02-01 00:00:00
abstract::Patients with antiphospholipid syndrome (APS) produce antiphospholipid antibodies (aPL) and develop vascular thrombosis that may occur in large or small vessels in the arterial or venous beds. On the other hand, many individuals produce aPL and yet never develop thrombotic events. Toll-like receptor 4 (TLR4) appears t...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315603146
更新日期:2016-02-01 00:00:00
abstract::Proteinuria is a well-known risk factor for the progression of renal dysfunction in chronic kidney disease; however, its importance for estimating the prognosis of lupus nephritis requires verification. Korean adult patients with renal biopsy-diagnosed diffuse proliferative lupus nephritis who had undergone three or m...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315595130
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:The objective of this paper is to assess whether pulmonary hypertension (PH) may be detected at one point in time or longitudinally predicted by serum uric acid (sUA) levels in systemic lupus erythematosus (SLE). METHODS:We conducted a post-hoc analysis of a long-term followed cohort of Mexican SLE patients....
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315600539
更新日期:2016-01-01 00:00:00
abstract::In vitro data showed that immunoglobulin G (IgG) from lupus nephritis (LN) patients could bind to proximal renal tubular epithelial cells (PTEC), but the clinical relevance of such binding remained unclear. Binding of IgG and subclasses to PTEC was measured by cellular ELISA (expressed as OD index) in 189 serial serum...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315598018
更新日期:2016-01-01 00:00:00